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GENERIC NAME: azathioprine
BRAND NAME: Imuran, Azasan

DRUG CLASS AND MECHANISM: Azathioprine is an immunosuppressant, that is, a drug that is used to suppress the immune system. It is used to treat patients who have undergone kidney transplantation and for diseases in which activity of the immune system is important. Azathioprine is a prodrug (a precursor of a drug) which is converted in the body to its active form called mercaptopurine (Purinethol). The exact mechanism of action of azathioprine is not known.

Like other immunosuppressants, it suppresses the proliferation of T and B lymphocytes, types of white blood cells that are part of the immune system and defend the body against both infectious diseases and foreign materials. For example, in the case of organ transplantation, immunosuppressants prevent the body from immunologically rejecting the new organ. In the case of autoimmune diseases (diseases caused by an abnormal immune reaction against the body's own tissues) such as rheumatoid arthritis, suppressing the immune system reduces the inflammation that accompanies immune reactions and slows damage to the joints caused by the inflammation.

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Promising Ways to Treat Rheumatoid Arthritis

Rheumatoid arthritis is a painful condition of body joints, mostly affecting wrist and knee joints. Although at present there is no permanent cure for rheumatoid arthritis, the irritating symptoms can be controlled by pharmacological as well as non-pharmacological means. All treatments reduce the suffering of the patient and improve the quality of life, making living with this condition less troublesome.

Several anti-inflammatory and pain relieving drugs are used to retard the progression of the symptoms associated with this disease. Non steroidal anti-inflammatory drug (NSAID) controls pain and inflammation. In combination with other drugs, it even prevents joint damage.

Disease-modifying anti-rheumatic drugs (DMARDs) such as methotrexate, Arava, Azulfidine, Cytoxan, Imuran, Neoral, and Plaquenil stop disease progression. They suppress the immune system, as well as the symptoms arising due to hyper immune action. These drugs, especially, methotrexate preserve the joint lining and its function. In severe pain, sometimes doctors may prescribe steroids to relieve pain and hardness. It is given temporarily for calming sudden flare.